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Role of AMPA receptors in synaptic plasticity.
- Source :
-
Cell & Tissue Research . Oct2006, Vol. 326 Issue 2, p447-455. 9p. - Publication Year :
- 2006
-
Abstract
- The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the principal molecular units for fast excitatory synaptic transmission in the central nervous system. The glutamate-mediated transmission efficiency of synaptic AMPA receptors is influenced by their subunit composition (GluR-A to GluR-D), post-transcriptional and post-translational modifications, the number of synaptic AMPA receptors, and auxiliary proteins. Functional AMPA receptors are located predominantly in the post-synapse but are also found at extra-synaptic sites and occasionally in the pre-synapse. Thus, many factors influence the tasks of AMPA receptors in neuronal signal transmission. At hippocampal synaptic connections, AMPA receptor functions have been well studied in vitro and in the mouse; however, it is unlikely that these observations can be generalized to all glutamatergic synapses in the brain. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0302766X
- Volume :
- 326
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cell & Tissue Research
- Publication Type :
- Academic Journal
- Accession number :
- 22458533
- Full Text :
- https://doi.org/10.1007/s00441-006-0275-4