Back to Search
Start Over
Effects of Androgen Disruption by DDE on the Development and Functioning of the Immune System in Japanese Quail*.
- Source :
-
Immunopharmacology & Immunotoxicology . Aug2006, Vol. 28 Issue 3, p535-544. 10p. - Publication Year :
- 2006
-
Abstract
- We hypothesized that immunosuppression in birds that is caused by exposure to antiandrogenic chemicals occurs mainly through disruption of the development of the androgen-sensitive avian lymphoid organ, the bursa of Fabricius. Injections of 20.0 or 40.0 μg of p,p'-DDE [ethylene, 1,1-dichloro-2,2-bis(p-chlorophenyl)], an antiandrogen, were administered at embryonic day 1. Bursas from only chicks treated with DDE were larger than, had fewer follicles, and exhibited vacuolization within follicles compared with controls; spleens were unaffected. No differences in either immune response test were observed. This study demonstrates that the bursa may play a role in androgen-active endocrine disrupting chemical-induced immunosuppression. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08923973
- Volume :
- 28
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Immunopharmacology & Immunotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 22455523
- Full Text :
- https://doi.org/10.1080/08923970600927850