Back to Search
Start Over
Decreased Cocaine Self-Administration in Kir3 Potassium Channel Subunit Knockout Mice.
- Source :
-
Neuropsychopharmacology . May2003, Vol. 28 Issue 5, p932-938. 7p. 1 Chart, 2 Graphs. - Publication Year :
- 2003
-
Abstract
- Multiple G protein-linked neurotransmitter systems have been implicated in the behavioral effects of cocaine. While actions of certain neurotransmitter receptor subtypes and transporters have been identified, the role of individual G protein-regulated enzymes and ion channels in the effects of cocaine remains unclear. Here, we assessed the contribution of G protein-gated, inwardly rectifying potassium (Kir3/GIRK) channels to the locomotor-stimulatory and reinforcing effects of cocaine using knockout mice lacking one or both of the key neuronal channel subunits, Kir3.2 and Kir3.3. Cocaine-stimulated increases in horizontal locomotor activity in wild-type, Kir3.2 knockout, Kir3.3 knockout, and Kir3.2/3.3 double knockout mice, with only minor differences observed between the mouse lines. In contrast, Kir3.2 and Kir3.3 knockout mice exhibited dramatically reduced intravenous self-administration of cocaine relative to wild-type mice over a range of cocaine doses. Paradoxically, Kir3.2/3.3 double knockout mice self-administered cocaine at levels significantly higher than either single knockout alone. These findings suggest that Kir3 channels play significant and complex roles in the reinforcing effect of cocaine. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COCAINE
*MICE
*POTASSIUM
*NARCOTICS
*TROPANES
Subjects
Details
- Language :
- English
- ISSN :
- 0893133X
- Volume :
- 28
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 22428975
- Full Text :
- https://doi.org/10.1038/sj.npp.1300100