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Determination of metoprolol tartrate in tablets and human urine using flow-injection chemiluminescence method
- Source :
-
Journal of Pharmaceutical & Biomedical Analysis . Sep2006, Vol. 42 Issue 3, p384-388. 5p. - Publication Year :
- 2006
-
Abstract
- Abstract: In this paper, a simple, rapid and sensitive flow-injection chemiluminescence method has been developed for the determination of metoprolol tartrate, which acts as a kind of sensitizer in the chemiluminescence emission from the redox of SO3 2− with Ce(IV) in acidic medium. Under the optimized conditions, the proposed method allows the measurement of metoprolol tartrate over the range of 1.5×10−8 to 7.3×10−6 mol/L with a detection limit of 4.7×10−9 mol/L (3σ), and the relative standard deviation for 7.3×10−7 mol/L metoprolol tartrate (n =11) is 2.20%. The utility of this method was demonstrated by determining metoprolol tartrate in tablets and human urine sample. [Copyright &y& Elsevier]
- Subjects :
- *CHEMILUMINESCENCE
*LUMINESCENCE
*ADRENERGIC beta blockers
*CARDIOVASCULAR agents
Subjects
Details
- Language :
- English
- ISSN :
- 07317085
- Volume :
- 42
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Pharmaceutical & Biomedical Analysis
- Publication Type :
- Academic Journal
- Accession number :
- 22280257
- Full Text :
- https://doi.org/10.1016/j.jpba.2006.04.008