Determination of metoprolol tartrate in tablets and human urine using flow-injection chemiluminescence method

Abstract: In this paper, a simple, rapid and sensitive flow-injection chemiluminescence method has been developed for the determination of metoprolol tartrate, which acts as a kind of sensitizer in the chemiluminescence emission from the redox of SO3 2− with Ce(IV) in acidic medium. Under the optimized conditions, the proposed method allows the measurement of metoprolol tartrate over the range of 1.5×10−8 to 7.3×10−6 mol/L with a detection limit of 4.7×10−9 mol/L (3σ), and the relative standard deviation for 7.3×10−7 mol/L metoprolol tartrate (n =11) is 2.20%. The utility of this method was demonstrated by determining metoprolol tartrate in tablets and human urine sample. [Copyright &y& Elsevier]