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Safety, reactogenicity, and immunogenicity of live attenuated varicella vaccine in children between 1 and 9 years of age with atopic dermatitis.
- Source :
-
European Journal of Pediatrics . Oct2006, Vol. 165 Issue 10, p677-683. 7p. 5 Charts, 1 Graph. - Publication Year :
- 2006
-
Abstract
- <bold>Introduction: </bold>Infection with varicella-zoster virus (VZV) is known to facilitate secondary bacterial infection, which is cause for particular concern in children with atopic dermatitis. This 2-year study assessed the safety, reactogenicity, and immunogenicity of a live attenuated Oka strain varicella vaccine (Varilrix, GlaxoSmithKline Biologicals) in 160 children aged 1-9 years with atopic dermatitis randomized to vaccination at the start of either the 1st or 2nd study year (VAR-1Y and VAR-2Y, respectively). Mean SCORing Atopic Dermatitis (SCORAD) scores at baseline were 19.3+/-11.1 and 26.0+/-10.4 in the two groups, respectively.<bold>Results: </bold>Varicella vaccination did not adversely affect the severity of atopic dermatitis, with analysis of variance (ANOVA) confirming equivalence for the change in SCORAD index from baseline to week 8 between vaccinated and unvaccinated subjects. Within-group comparison of post-vaccination changes in SCORAD index from baseline to week 8 and month 12 in the VAR-2Y group showed a greater reduction in mean SCORAD scores following vaccination in year 2 than in year 1 when subjects were unvaccinated. Overall, SCORAD indices fell by approximately 10 points in both study groups over the 2 years of follow-up. Varicella vaccination was well tolerated, with no children withdrawn due to adverse events. Injection site redness was the most frequent solicited adverse event, occurring in 17.1% of subjects. Seroconversion rates were 94.3% at week 8 and 88.9% at month 12. In all, 43.6% of vaccinees reported at least one varicella contact during the course of the study. However, none developed varicella infection after vaccination over the 2 years of follow-up.<bold>Conclusion: </bold>In summary, vaccination with a live attenuated varicella vaccine appears safe and effective in children with atopic dermatitis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNIZATION
*VARICELLA-zoster virus
*MEDICAL research
*ATOPIC dermatitis
*VACCINATION
*CHICKENPOX
*ANALYSIS of variance
*COMPARATIVE studies
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*SAFETY
*VIRAL antibodies
*EVALUATION research
*RANDOMIZED controlled trials
*CHICKENPOX vaccines
*PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 03406199
- Volume :
- 165
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- European Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 22081565
- Full Text :
- https://doi.org/10.1007/s00431-006-0103-6