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Troglitazone and 9cis,11trans,13trans-Conjugated Linolenic Acid: Comparison of Their Antiproliferative and Apoptosis-Inducing Effects on Different Colon Cancer Cell Lines.
- Source :
-
Chemotherapy (0009-3157) . 2006, Vol. 52 Issue 5, p220-225. 6p. 1 Diagram, 4 Graphs. - Publication Year :
- 2006
-
Abstract
- Background: We have previously reported that troglitazone, a synthetic ligand for peroxisome proliferator-activated receptor γ (PPARγ), and bitter gourd seed oil rich in 9cis,11trans,13trans-conjugated linolenic acid (9c,11t,13t-CLN) prevent colon carcinogenesis. To evaluate the chemotherapeutic effect and potency of these compounds on colon cancer cells, we investigated their antiproliferative and apoptosis-inducing effects using different human colon cancer cell lines. Methods: The antiproliferative and apoptosis-inducing effects of troglitazone and 9c,11t,13t-CLN were evaluated and compared using HT-29, DLD-1 and Caco-2 cells at different stages of enterocytic differentiation. Results: Troglitazone and 9c,11t,13t-CLN decreased cell viability and induced apoptosis in three colon cancer cell lines. The susceptibility of HT-29, which expresses PPARγ at high levels, to troglitazone and 9c,11t,13t-CLN was higher than that of Caco-2 cells with low levels of PPARγ. Conclusion: Troglitazone and 9c,11t,13t-CLN exhibited more effective chemotherapeutic effects on HT-29 cells than on Caco-2 cells. Copyright © 2006 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIGANDS (Biochemistry)
*PEROXISOMES
*LINOLENIC acids
*CANCER cells
*DRUG therapy
Subjects
Details
- Language :
- English
- ISSN :
- 00093157
- Volume :
- 52
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Chemotherapy (0009-3157)
- Publication Type :
- Academic Journal
- Accession number :
- 22040325
- Full Text :
- https://doi.org/10.1159/000094865