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A Primary Pure Yolk Sac Tumor of the Lung Exhibiting CDX-2 Immunoreactivity and Increased Serum Levels of Alkaline Phosphatase Intestinal Isoenzyme.
- Source :
-
International Journal of Surgical Pathology . Jul2006, Vol. 14 Issue 3, p247-251. 5p. - Publication Year :
- 2006
-
Abstract
- Malignant extragonadal germ cell tumors primary to the lung are quite uncommon lesions, but pure yolk sac tumor is even more exceptional. This is believed to be the first reported case of yolk sac tumor of the lung in which an intense and diffuse immunoreactivity for CDX2, a marker of intestinal differentiation reportedly expressed also in gonadal yolk sac tumor, was associated with increased serum levels of the alkaline phosphatase intestinal isoform. Nine months after radical surgery and adjuvant chemotherapy, the patient is alive and well without evidence of recurrent or metastatic disease and with serum levels of the alkaline phosphatase intestinal isoform within normal limits. The pathologist should be aware of yolk sac tumor arising in the lung and that alkaline phosphatase intestinal isoform could become an additional serum marker for such a tumor. [ABSTRACT FROM AUTHOR]
- Subjects :
- *YOLK sac
*LUNG tumors
*ALKALINE phosphatase
*ISOENZYMES
*PATHOLOGY
PLACENTA tumors
Subjects
Details
- Language :
- English
- ISSN :
- 10668969
- Volume :
- 14
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- International Journal of Surgical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 22027653
- Full Text :
- https://doi.org/10.1177/1066896906290657