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GABA B receptor‐mediated modulation of glutamate signaling in cerebellar Purkinje cells.
- Source :
-
Cerebellum . Jun2006, Vol. 5 Issue 2, p127-133. 7p. 1 Diagram, 2 Graphs. - Publication Year :
- 2006
-
Abstract
- Since Purkinje cells are the sole output neurons of the cerebellar cortex, the postsynaptic integration of excitatory and inhibitory synaptic inputs in this cell type is a pivotal step for cerebellar motor information processing. In Purkinje cells, G i/o protein‐coupled B‐type γ‐aminobutyric acid receptor (GABA B R) is expressed at the annuli of the dendritic spines that are innervated by the glutamatergic terminals of parallel fibers. The subcellular localization of GABA B R suggests the possibility of postsynaptic interplay between GABA B R and glutamate signaling. It has recently been demonstrated that GABA B R indeed modulates α amino‐3‐hydroxy‐5‐methyl‐4‐isoxalone propionate‐type ionotropic glutamate receptor (AMPAR)‐mediated and type‐1 metabotropic glutamate receptor (mGluR1)‐mediated signaling. Interestingly, GABA B R exerts modulatory actions not only via the classical G i/o protein‐dependent signaling cascade but also via a G i/o protein‐independent interaction between GABA B R and mGluR1. In this review, we compare the physiological nature, underlying mechanisms, and possible functional significance of these modulatory actions of GABA B R. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PURKINJE cells
*NEURONS
*CEREBELLAR cortex
*CELL receptors
*SYNAPSES
*NERVOUS system
Subjects
Details
- Language :
- English
- ISSN :
- 14734222
- Volume :
- 5
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cerebellum
- Publication Type :
- Academic Journal
- Accession number :
- 22018592
- Full Text :
- https://doi.org/10.1080/14734220600788911