Extensive but coordinated reorganization of the membrane skeleton in myofibers of dystrophic...

Examines the organization of the membrane skeletal proteins of dystrophic (mdx) mice using immunofluorescence techniques and confocal imaging. Absence of beta-spectrin from the sarcolemma; Concentration of membrane proteins in costameres, in control myofibers, and mdx muscle; Codistribution of utrophin with beta-spectrin in the mutant sarcolemma.