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Chronic Stress Impairs Spatial Memory and Motivation for Reward Without Disrupting Motor Ability and Motivation to Explore.
- Source :
-
Behavioral Neuroscience . Aug2006, Vol. 120 Issue 4, p842-851. 10p. 5 Graphs. - Publication Year :
- 2006
-
Abstract
- This study uses an operant, behavioral model to assess the daily changes in the decay rate of short-term memory, motivation, and motor ability in rats exposed to chronic restraint. Restraint decreased reward-related motivation by 50% without altering memory decay rate or motor ability. Moreover, chronic restraint impaired hippocampal-dependent spatial memory on the Y maze (4-hr delay) and produced CA3 dendritic retraction without altering hippocampal-independent maze navigation (1-min delay) or locomotion. Thus, mechanisms underlying motivation for food reward differ from those underlying Y maze exploration, and neurobiological substrates of spatial memory, such as the hippocampus, differ from those that underlie short-term memory. Chronic restraint produces functional, neuromorphological, and physiological alterations that parallel symptoms of depression in humans. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07357044
- Volume :
- 120
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Behavioral Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 21997636
- Full Text :
- https://doi.org/10.1037/0735-7044.120.4.842