Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase.

Examines mice deficient in the Nox2 catalytic subunit of nicotinamide adenoside dinucleotide phosphate (NADPH) oxidase and wild-type littermate controls to probe the potential role of NADPH oxidase in aldosterone-induced cardiac fibrosis and the involvement of this mechanism in angiotensin II (AngII)-induced effects. Involvement of mineralocorticoid receptor (MR) activation in the NADPH oxidase response to AngII; Role of Nox2 in MR-dependent fibrosis in vivo; Critical events in the cardiac fibrosis induced by AngII.