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The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.
- Source :
-
Biochemistry . 07/13/99, Vol. 38 Issue 28, p8892. 7p. 8 Diagrams, 1 Chart. - Publication Year :
- 1999
-
Abstract
- Presents evidence correlating the mobility of an HIV-1 integrase active site loop to catalytic activity. Covalent integration of the viral cDNA into the host chromosomal DNA in the replication of HIV-1; Conformational flexibility of the active site loop; Catalysis after DNA binding.
- Subjects :
- *HIV
*VIRAL genetics
*VIRUS-induced enzymes
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 38
- Issue :
- 28
- Database :
- Academic Search Index
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 2170956
- Full Text :
- https://doi.org/10.1021/bi9907173