Back to Search
Start Over
Intracellular water homeostasis and the mammalian cellular osmotic stress response.
- Source :
-
Journal of Cellular Physiology . Jan2006, Vol. 206 Issue 1, p9-15. 7p. 2 Color Photographs, 2 Charts. - Publication Year :
- 2006
-
Abstract
- The cellular response to osmotic stress ensures that the concentration of water inside the cell is maintained within a range that is compatible with biologic function. Single cell organisms are particularly dependent on mechanisms that permit adaptation to osmotic stress because each individual cell is directly exposed to the external environment. Mammals, however, limit osmotic stress by establishing an internal aqueous environment in which intravascular water and electrolytes are subject to sensitive and dynamic, organism-based homeostatic regulation. Recent studies of NFAT5/TonEBP, an essential mammalian osmoregulatory transcription factor, demonstrate the unexpected yet critical significance of cell-based osmotic regulation in vivo. These results highlight the fundamental importance of maintaining intracellular water homeostasis in the face of varying cellular metabolic activity and distinct tissue microenvironments. © 2005 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HOMEOSTASIS
*MAMMALS
*ELECTROLYTES
*TRANSCRIPTION factors
*PROTEINS
*CELL physiology
Subjects
Details
- Language :
- English
- ISSN :
- 00219541
- Volume :
- 206
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Cellular Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 21619691
- Full Text :
- https://doi.org/10.1002/jcp.20445