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Unilateral lesion of the subthalamic nucleus enhances cortical fos expression associated with focally evoked seizures in the rat
- Source :
-
Brain Research . Jul2006, Vol. 1101 Issue 1, p145-150. 6p. - Publication Year :
- 2006
-
Abstract
- Abstract: Reducing subthalamic nucleus (STN) activity has been proposed as an anti-epileptic procedure. Here we show that, on the contrary, a unilateral lesion of the STN causes slight (nonsignificant) increases in the severity of limbic seizures evoked by bicuculline infusion into the piriform cortex, associated with marked Fos expression throughout the cerebral cortex. Abolishing the STN control over the basal ganglia output may therefore play a facilitatory role on cortical activation associated with limbic seizures. [Copyright &y& Elsevier]
- Subjects :
- *CEREBRAL cortex
*EPILEPSY
*BRAIN diseases
*SUBTHALAMUS
Subjects
Details
- Language :
- English
- ISSN :
- 00068993
- Volume :
- 1101
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Brain Research
- Publication Type :
- Academic Journal
- Accession number :
- 21577089
- Full Text :
- https://doi.org/10.1016/j.brainres.2006.05.025