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Autologous full-thickness skin substitute for healing chronic wounds.
- Source :
-
British Journal of Dermatology . Aug2006, Vol. 155 Issue 2, p267-274. 8p. 2 Diagrams, 2 Charts. - Publication Year :
- 2006
-
Abstract
- Background Chronic wounds represent a major problem to our society. Therefore, advanced wound-healing strategies for the treatment of these wounds are expanding into the field of tissue engineering. Objectives To develop a novel tissue-engineered, autologous, full-thickness skin substitute of entirely human origin and to determine its ability to heal chronic wounds. Methods Skin substitutes (fully differentiated epidermis on fibroblast-populated human dermis) were constructed from 3-mm punch biopsies isolated from patients to be treated. Acellular allodermis was used as a dermal matrix. After a prior 5-day vacuum-assisted closure therapy to prepare the wound bed, skin substitutes were applied in a simple one-step surgical procedure to 19 long-standing recalcitrant leg ulcers (14 patients; ulcer duration 0·5–50 years). Results The success rate in culturing biopsies was 97%. The skin substitute visibly resembled an autograft. Eleven of the 19 ulcers (size 1–10 cm2) healed within 8 weeks after a single application of the skin substitute. The other eight larger (60–150 cm2) and/or complicated ulcers healed completely ( n = 5) or continued to decrease substantially in size ( n = 3) after the 8-week follow-up period. Wound healing occurred by direct take of the skin substitute ( n = 12) and/or stimulation of granulation tissue/epithelialization ( n = 7). Skin substitutes were very well tolerated and pain relief was immediate after application. Conclusions Application of this novel skin substitute provides a promising new therapy for healing chronic wounds resistant to conventional therapies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00070963
- Volume :
- 155
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- British Journal of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 21523476
- Full Text :
- https://doi.org/10.1111/j.1365-2133.2006.07266.x