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Fetal hepatic haematopoiesis is modulated by arterial blood flow to the liver.
- Source :
-
British Journal of Haematology . Aug2006, Vol. 134 Issue 3, p330-332. 3p. 2 Graphs. - Publication Year :
- 2006
-
Abstract
- We describe an as yet unrecognised relationship between fetal hepatic haematopoiesis and arterial blood flow to the liver. To increase hepatic arterial flow, the common bile duct (CBD) was ligated in fetal lambs. Reduction of hepatic arterial flow was accomplished in age-matched animals by hepatic artery (HA) ligation. Multiple analyses performed before term showed a significant increase in haematopoietic cell density in CBD animals when compared with sham controls and HA animals. In contrast, HA animals demonstrated a decrease in liver haematopoietic activity. Fetal hepatic haematopoiesis is dependent upon arterial blood flow to the liver. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD flow
*LIVER cells
*BILE ducts
*BLOOD vessels
*LIVER
*FETUS
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 134
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 21396658
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2006.06183.x