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Therapeutic potential of resveratrol: the in vivo evidence.
- Source :
-
Nature Reviews Drug Discovery . Jun2006, Vol. 5 Issue 6, p493-506. 14p. 2 Diagrams, 3 Charts, 1 Graph. - Publication Year :
- 2006
-
Abstract
- Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14741776
- Volume :
- 5
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Nature Reviews Drug Discovery
- Publication Type :
- Academic Journal
- Accession number :
- 21143460
- Full Text :
- https://doi.org/10.1038/nrd2060