Back to Search
Start Over
Adjuvant effect of mushroom glucan and bovine lactoferrin upon Aeromonas hydrophila vaccination in catla, Catla catla (Hamilton).
- Source :
-
Journal of Fish Diseases . Jun2006, Vol. 29 Issue 6, p331-337. 7p. 4 Charts. - Publication Year :
- 2006
-
Abstract
- Mushroom glucan and bovine lactoferrin (Lf), known for their immunostimulatory potential, were used as adjuvant in conjunction with a formalin-killed Aeromonas hydrophila vaccine in catla, Catla catla. In vitro antigen-specific responsiveness of catla leucocytes and protective responses against experimental challenge with homologous antigen were monitored following immunization. Antigen-specific proliferation, ‘macrophage activating factor’ (MAF) production and antibody production were significantly higher in fish injected with glucan adjuvanted vaccine. Lf adjuvanted preparations showed a weak proliferative response and MAF production, although the antibody production was significantly higher than the controls. A good degree of protection was achieved with the glucan adjuvanted vaccine. However, in spite of producing significant anti- A. hydrophila antibody, Lf adjuvanted vaccine did not confer any protection following challenge with A. hydrophila. The potential of adjuvanticity of mushroom glucan and bovine Lf in intraperitoneal vaccination is discussed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AEROMONAS hydrophila
*VACCINE research
*CATLA catla
*VIRAL antibodies
Subjects
Details
- Language :
- English
- ISSN :
- 01407775
- Volume :
- 29
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Fish Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 21063947
- Full Text :
- https://doi.org/10.1111/j.1365-2761.2006.00722.x