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CSF hypocretin-1 measurement in pediatric and teenage patients with sleep disorders.
- Source :
-
Sleep & Biological Rhythms . Jun2006, Vol. 4 Issue 2, p186-189. 4p. 1 Chart, 1 Graph. - Publication Year :
- 2006
-
Abstract
- Narcolepsy and other sleep disorders are underrecognized in children; therefore, the final diagnosis and initiation of treatment is often delayed. This is due to the fact that the expression of sleep-related symptoms in children is often different from those of adults and polysomnography is generally difficult in children. CSF hypocretin-1 (orexin-A) measurement in adults demonstrated that low levels are highly specific to narcolepsy and this examination is now being established as a new diagnostic tool. In this study, we describe the spectrum of the hypocretin deficiency syndrome by analysis of CSF hypocretin-1 levels and clinical, polysomnography and human leukocyte antigen data in 38 pediatric and teenage patients with various sleep disorders and 120 patients with neurological conditions. The levels of CSF hypocretin-1 were significantly lower in narcolepsy compared to other neurological conditions. The measurement of hypocretin-1 is a useful diagnostic tool in pediatric narcolepsy, especially when other diagnostic information (e.g. polysomnography and human leukocyte antigen) is not sufficient. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NARCOLEPSY
*SLEEP disorders
*CHILDREN
*SYMPTOMS
*POLYSOMNOGRAPHY
Subjects
Details
- Language :
- English
- ISSN :
- 14469235
- Volume :
- 4
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Sleep & Biological Rhythms
- Publication Type :
- Academic Journal
- Accession number :
- 21053254
- Full Text :
- https://doi.org/10.1111/j.1479-8425.2006.00217.x