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Novel route for the transformation of a pyrimidine ring using hydrazides.
- Source :
-
Chemistry of Heterocyclic Compounds . Feb2006, Vol. 42 Issue 2, p233-245. 13p. 2 Diagrams, 8 Charts. - Publication Year :
- 2006
-
Abstract
- It has been shown from X-ray structural analytical data that the reaction of 2-ethoxycarbonylmethyl-1,4,6-trimethylpyrimidinium iodide with carboxylic acid hydrazides gives pyrazolo[1,5-a]pyrimidine derivatives and not the isomeric triazolo[4,3-a]pyridines previously reported. This novel and previously unreported rearrangement of 1,2-dialkylpyrimidinium salts occurs via recyclization of the pyrimidine ring with inclusion of a fragment of the nucleophilic reagent into the transformation product. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARBOXYLIC acids
*PYRIMIDINES
*HETEROCYCLIC compounds
*PYRIDINE
*CHEMICAL reactions
Subjects
Details
- Language :
- English
- ISSN :
- 00093122
- Volume :
- 42
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Chemistry of Heterocyclic Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 20878614
- Full Text :
- https://doi.org/10.1007/s10593-006-0077-3