Making the paper: Alan Aderem.

The article focuses on the efforts of co-director Alan Aderem and his colleagues in elucidating the complex networks that regulate the body's immune system. They are using both computational and experimental approaches, with each of the techniques informing and validating the others. The team has suspected that any transcription factors in the first set of genes would turn on genes in the second set, and transcription factors in that set would turn on genes in the third, and so forth.