The changing face of treatment for Crohn's disease.

The article focuses on the treatment for Crohn's disease in Great Britain. Therapies of proven efficacy include systemic corticosteroids, budesonide and antibodies against tumor necrosis factor α infliximab. The mucosal inflammation of established Crohn's disease is dominated by CD4-positive T lymphocytes with a type 1 helper phenotype, characterize by the production of interferon-y and TNF-α. The process involves extravasation of leucocytes from the blood-stream into the tissues of the bowel.