Back to Search
Start Over
Cytotoxic Alangium alkaloids from Alangium longiflorum
- Source :
-
Phytochemistry . May2006, Vol. 67 Issue 9, p894-897. 4p. - Publication Year :
- 2006
-
Abstract
- Abstract: Seven alkaloids (1–7) were isolated from the stem bark of Alangium longiflorum. Compound 1, (−)-10-O-demethylisocephaeline, was isolated for the first time as a naturally occurring product from a plant source. All structures were elucidated by detailed spectroscopic analysis. Biological evaluation showed that 2, 10-O-demethylcephaeline, exhibited potent cytotoxic activity against human lung carcinoma (A549) and breast adenocarcinoma (MCF-7) with ED50 values of 0.013 and 0.062μM, respectively. The stereoisomer 1 was less potent than 2, and related compounds with different hydroxy/methoxy substitution patterns were also less potent or inactive. Thus, compound 2 merits attention as a cytotoxic lead for further study. [Copyright &y& Elsevier]
- Subjects :
- *ALANGIUM
*STEREOISOMERS
*ALKALOIDS
*SPECTRUM analysis
Subjects
Details
- Language :
- English
- ISSN :
- 00319422
- Volume :
- 67
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20554808
- Full Text :
- https://doi.org/10.1016/j.phytochem.2006.01.009