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Norbornyllactone-substituted xanthines as adenosine A1 receptor antagonists
- Source :
-
Bioorganic & Medicinal Chemistry . Jun2006, Vol. 14 Issue 11, p3654-3661. 8p. - Publication Year :
- 2006
-
Abstract
- Abstract: During the search for second-generation adenosine A1 receptor antagonist alternatives to the clinical candidate 8-(3-oxa-tricyclo[3.2.1.02,4]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (BG9719), we developed a series of novel xanthines substituted with norbornyl-lactones that possessed high binding affinities for adenosine A1 receptors and in vivo activity. [Copyright &y& Elsevier]
- Subjects :
- *ADENOSINES
*XANTHINE
*LACTONES
*ORGANIC cyclic compounds
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 14
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20551689
- Full Text :
- https://doi.org/10.1016/j.bmc.2006.01.021