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CD5+ B cells are preferentially expanded in rabbit appendix: The role of CD5 in B cell development and selection
- Source :
-
Developmental & Comparative Immunology . Sep2006, Vol. 30 Issue 8, p711-722. 12p. - Publication Year :
- 2006
-
Abstract
- Abstract: Although only a small proportion of mouse and human B cells are CD5+, most adult rabbit B cells express CD5. However, CD5 was not detectable on the majority of B cells in neonatal appendix 1 and 3days after birth. Cell trafficking studies demonstrated that CD5+ and CD5− CD62L+ B cells from bone marrow migrated into appendix. There, CD5+ B cells were preferentially expanded and predominated by ∼2weeks of age. In mutant ali/ali rabbits, VHa2+ B cells develop through gene conversion-like alteration of rearranged VH genes upstream of deleted VH1a2. Correlated appearance of individual CD5+ germinal centers and VHa2+ B-cells in mutant appendix suggests that CD5 binding positively selects cells with a2+ framework regions that bind CD5. Following negative and positive selection, cells with diversified rearranged heavy- and light-chain sequences exit appendix, migrate to peripheral tissues and constitute the preimmune repertoire of CD5+ B cells that encounter foreign antigens. [Copyright &y& Elsevier]
- Subjects :
- *B cells
*RABBITS
*BONE marrow
*APPENDIX (Anatomy)
Subjects
Details
- Language :
- English
- ISSN :
- 0145305X
- Volume :
- 30
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Developmental & Comparative Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 20536574
- Full Text :
- https://doi.org/10.1016/j.dci.2005.10.001