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Optimization of 2-aminothiazole derivatives as CCR4 antagonists
- Source :
-
Bioorganic & Medicinal Chemistry Letters . May2006, Vol. 16 Issue 10, p2800-2803. 4p. - Publication Year :
- 2006
-
Abstract
- Abstract: A series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor evaluated using a [125I]TARC (CCL17) displacement assay. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent, orally bioavailable antagonists. [Copyright &y& Elsevier]
- Subjects :
- *CHEMICAL inhibitors
*HORMONE antagonists
*CELL receptors
*PHARMACOKINETICS
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 16
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 20524741
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.01.126