Millisecond-timescale motions contribute to the function of the bacterial response regulator protein Spo0F.

Presents a research on the mechanism of action of the Bacillus subtilis response regulator Spo0F, exploring the relationship between the motional characteristics and protein-protein interactions. Use of a set of nuclear magnetic resonance N relaxation measurements to determine the relative timescales of Spo0F backbone fluctuations on the picosecond-to-millisecond timescale; Demonstration that regions having motion on the millisecond timescale correlate with residues and surfaces that are known to be critical for protein-protein interactions.