Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation.

Presents a study which determined the possible mechanism by which MDL 28170 modulates Aβ formation by examining its effects on the three intramembrane cleavages of amyloid precursor protein. Effect of MDL 28170 at low concentrations; Experiment done to determine the effect of MDL 28170 on the formation of these Aβ species; Conclusions and significance of the study.