High-Throughput Enzymatic Method for Enantiomeric Excess Determination of 0-Acetylated Cyanohydrins.

The article discusses the use of high-throughput enzymatic method for enantiomeric excess determination of O-acetylated cyanohydrins. New catalysts for asymmetric synthesis can be discovered using high-throughput methods. Lack of general techniques for efficient enantiomeric excess determinations has been a major constraint in developing parallel screening methods for assessing catalyst performance. Highly enantioenriched O-acetylated cyanohydrins have been prepared from aldehydes and acetyl cyanide using a highly efficient catalytic system.