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Time-course changes in the expression of heme oxygenase-1 in human subcutaneous hemorrhage

Authors :
Nakajima, Toru
Hayakawa, Mutsumi
Yajima, Daisuke
Motani-Saitoh, Hisako
Sato, Yayoi
Kiuchi, Masahiro
Ichinose, Masaharu
Iwase, Hirotaro
Source :
Forensic Science International. May2006, Vol. 158 Issue 2/3, p157-163. 7p.
Publication Year :
2006

Abstract

Abstract: To determine the time-course of human subcutaneous hemorrhage, heme oxygenase (HO)-1 expression and macrophage infiltration were observed using an immunohistochemical technique and semiquantitative analysis. The number of immunoreactive cells and the number of all infiltrating cells of each microscopic field were counted, and the ratio of the former to the latter was calculated as the positive cells ratio. An increase in the HO-1-positive cells ratio was observed starting at 3h after injury, and the maximum ratio was observed 3 days after injury. The pattern of the increase in the macrophage ratio was similar to that of the HO-1-positive cells ratio in the early period after injury. Observation of serial sections revealed that the expression of HO-1 in the cells corresponded to the localization of macrophage. The present results suggest that the determination of HO-1 expression, as derived from macrophages, might be useful for the estimation of the time-course of subcutaneous hemorrhage. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
03790738
Volume :
158
Issue :
2/3
Database :
Academic Search Index
Journal :
Forensic Science International
Publication Type :
Academic Journal
Accession number :
20185173
Full Text :
https://doi.org/10.1016/j.forsciint.2005.05.028