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Substituted coumarins as potent 5-lipoxygenase inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . May2006, Vol. 16 Issue 9, p2528-2531. 4p. - Publication Year :
- 2006
-
Abstract
- Abstract: Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure–activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme. [Copyright &y& Elsevier]
- Subjects :
- *COUMARINS
*BIOSYNTHESIS
*ASTHMA
*LIPOXYGENASES
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 16
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 20184167
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.01.085