Back to Search
Start Over
Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats.
- Source :
-
Psychopharmacology . Apr2006, Vol. 185 Issue 2, p248-254. 7p. 1 Chart, 4 Graphs. - Publication Year :
- 2006
-
Abstract
- Rationale and objectives: Previous work indicated that tolerance to the anorectic effect of the cannabinoid CB1 receptor antagonist/inverse agonist, rimonabant, developed rather rapidly in rats and mice given access to a standard rodent chow. The present study was designed to investigate whether the reducing effect of rimonabant on intake of a highly palatable food such as a chocolate-flavoured beverage underwent a development of tolerance as rapid as that manifested on intake of a standard rodent chow. Materials and methods: To this aim, Wistar rats were concurrently exposed, with unlimited access for 24 h/day, to the chocolate-flavoured beverage, regular food pellets and water. Rimonabant (0, 1.25, 2.5 and 5 mg/kg; i.p.) was administered once a day for 21 consecutive days. Results: Rimonabant administration resulted in a dose-dependent suppression of the high, daily intake of the chocolate-flavoured beverage; this effect lasted for the entire 21-day treatment period, without any apparent development of tolerance. Conversely, rimonabant-induced reduction in daily intake of regular food pellets was of a smaller magnitude and was limited to the first 3-4 days of treatment. Conclusions: Together, these results indicate that chronically administered rimonabant was more effective and longer-lasting in reducing the intake of a highly palatable food than that of regular food pellets in rats. These results also suggest that rimonabant may be more active on the hedonic rather than nutritive properties of diets. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANNABINOIDS
*CHOCOLATE
*BEVERAGES
*DIET
*RATS
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 00333158
- Volume :
- 185
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 20004815
- Full Text :
- https://doi.org/10.1007/s00213-006-0327-1