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PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.
- Source :
-
Journal of Clinical Investigation . Mar2006, Vol. 116 Issue 3, p615-622. 8p. 3 Diagrams, 2 Graphs. - Publication Year :
- 2006
-
Abstract
- Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 116
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 19988776
- Full Text :
- https://doi.org/10.1172/JCI27794