The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein.

Authors :: Lu, Pei-Jung
Wulf, Gerburg
Zhen Zhou, Xiao
Davies, Peter
Ping Lu, Kun
Source :: Nature. 6/24/1999, Vol. 399 Issue 6738, p784. 5p. 11 Color Photographs, 20 Diagrams, 1 Chart, 4 Graphs.
Publication Year :: 1999
Abstract: Presents research which studied the role of the protein tau in Alzheimer's disease. The neurofibrillary tangle of paired helical filaments (PHFs) composed of tau; Hyperphosphorylation and phosphorylation of tau; Binding site for the WW domain of the prolyl isomerase Pin1; Effects of Pin1 on mitosis; Depletion of soluble Pin1 in Alzheimer's patients, and its effects; Value of research.

Subjects :: *GENETICS of Alzheimer's disease
*ISOMERASES
*PROTEINS
*NERVE fibers
*PHYSIOLOGY

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