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Benzo[a]pyrene-enhanced mutagenesis by man-made mineral fibres in the lung of λ-lacI transgenic rats
- Source :
-
Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis . Mar2006, Vol. 595 Issue 1/2, p167-173. 7p. - Publication Year :
- 2006
-
Abstract
- Abstract: In an attempt to examine the interaction of man-made mineral fibres with benzo[a]pyrene (B[a]P), homozygous λ-lacI transgenic F344 rats were intratracheally treated with rock (stone) wool RW1 and glass wool MMVF 10 fibres together with B[a]P. To analyze the induction of gene mutations by fibres and B[a]P in lung, single doses of 1 and 2mg fibres/animal or multiple doses of 2mg fibres/animal were administered weekly on 4 consecutive weeks (total dose 8mg/animal). B[a]P (10mg/animal) was administered either simultaneously with fibres (for single dose treatment with fibres) or together with the last fiber treatment (for multiple dose treatment with fibres). Animals were scarified 4 weeks after the last treatment. Benzo[a]pyrene administered simultaneously with RW1 fibres exhibited a strong synergistic effect on mutagenicity, the observed mutant frequency (MF) being more than three-fold higher than the net sum of the MF induced after separate administration of both agents. Our data suggest that DNA adducts induced by simultaneous B[a]P and fiber treatment lead to a strong increase in mutatant frequencies. [Copyright &y& Elsevier]
- Subjects :
- *MUTAGENESIS
*TRANSGENIC animals
*ARTIFICIAL minerals
*RATS
Subjects
Details
- Language :
- English
- ISSN :
- 00275107
- Volume :
- 595
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
- Publication Type :
- Academic Journal
- Accession number :
- 19849584
- Full Text :
- https://doi.org/10.1016/j.mrfmmm.2005.11.003