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Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Apr2006, Vol. 16 Issue 7, p1954-1956. 3p. - Publication Year :
- 2006
-
Abstract
- Abstract: 1,3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps. [Copyright &y& Elsevier]
- Subjects :
- *IMIDAZOLES
*DERIVATIZATION
*TRANSFERASES
*ENZYME inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 16
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 19842158
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.12.074