Highly enantioselective Ru-catalyzed hydrogenation of β-keto esters using electron-donating bis(trialkylphosphine) ligand-TangPhos

Authors :: Wang, Chun-Jiang
Tao, Haiyan
Zhang, Xumu
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Mar2006, Vol. 47 Issue 12, p1901-1903. 3p.
Publication Year :: 2006
Abstract: Abstract: Highly electron-donating bis(trialkylphosphine) TangPhos and its corresponding ruthenium complexes provided high enantioselectivities for the hydrogenation of β-keto esters. Up to 99.8% and 99.5% ee have been achieved in hydrogenation of β-alkyl and β-aryl substituted β-keto esters, respectively. Asymmetric hydrogenation of ethyl 4-chloro acetoacetate in 98.2% ee is also reported. [Copyright &y& Elsevier]

Language :: English
ISSN :: 00404039
Volume :: 47
Issue :: 12
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 19768916
Full Text :: https://doi.org/10.1016/j.tetlet.2006.01.093

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