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Transfection of mouse macrophage metalloelastase gene into murine CT-26 colon cancer cells suppresses orthotopic tumor growth, angiogenesis and vascular endothelial growth factor expression
- Source :
-
Cancer Letters . Feb2006, Vol. 233 Issue 1, p139-150. 12p. - Publication Year :
- 2006
-
Abstract
- Abstract: A cDNA fragment coding for domains I and II of mouse macrophage metalloelastase (MME) was transfected into murine CT-26 colon cancer cells that are MME deficient. An orthotopic implantation model was established by using MME-transfected cells. In MME-transfected primary tumors, it demonstrated that tumor growth and microvessel formation were significantly inhibited compared with the controls. The expression of vascular endothelial growth factor (VEGF) mRNA and protein was significantly lower in MME-transfected group compared with those in the controls. Our data show that both MME and VEGF gene expression is highly associated with the vascularity of tumors, which may depend on a balance between MME and VEGF expression. [Copyright &y& Elsevier]
- Subjects :
- *CANCER cells
*TUMOR growth
*GENE expression
*ONCOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 233
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 19696472
- Full Text :
- https://doi.org/10.1016/j.canlet.2005.03.010