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A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities
- Source :
-
FEBS Letters . Feb2006, Vol. 580 Issue 3, p839-843. 5p. - Publication Year :
- 2006
-
Abstract
- Abstract: The cysteine in the M/IXXCW motif is conserved in all but one (threonine in place of cysteine) of the human protein tyrosine kinases (PTKs). We showed that all RET-PTC-1 mutants in which the C in this motif (C376) was replaced with glycine, lysine, threonine or serine lost their activity in vitro. However, the C376T/S mutants showed normal tyrosine phosphorylation in vivo (in cells). Further analyses reveled that protein kinase C (PKC) initiated the activities of the C376T/S mutants in cells. We conclude that the M/IXXCW motif-mediated mechanisms which initiate PTK activities are partially replaced by a PKC-mediated mechanism. [Copyright &y& Elsevier]
- Subjects :
- *PROTEIN-tyrosine kinases
*GLYCINE
*SERINE
*LYSINE
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 580
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 19598130
- Full Text :
- https://doi.org/10.1016/j.febslet.2006.01.005