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Economic Evaluation of Voriconazole versus Conventional Amphotericin B in the Treatment of Invasive Aspergillosis in Germany.
- Source :
-
Value in Health . Jan/Feb2006, Vol. 9 Issue 1, p12-23. 12p. 8 Charts. - Publication Year :
- 2006
-
Abstract
- Objective: To assess the costs and cost-effectiveness of voriconazole in comparison to conventional amphotericin B (CAB) for the treatment of invasive aspergillosis in Germany. Methods: The cost-effectiveness of voriconazole in comparison to CAB was evaluated with a lifetime Markov model, focusing on the long-term survival of patients treated for invasive aspergillosis. Long-term survival was extrapolated from survival after 12 weeks of treatment, obtained from a randomized aspergillosis study. Information on medical resource consumption and treatment pathways were obtained from this study and an expert committee. With probabilistic analysis the cost-effectiveness of voriconazole compared with amphotericin B was analyzed and expressed in incremental costs per life-weeks gained. The evaluation was performed from a limited societal perspective (both inpatient and outpatient costs) and hospital perspective (only inpatient costs). Results: Average survival of patients treated with voriconazole was 174.4 life-weeks (95% confidence interval [CI] 159.4–191.3), compared with 119.4 life-weeks (95% CI 106.4–132.3) for amphotericin B. With voriconazole, the mean total costs per patient were &U20AC;30,026 (95% CI &U20AC;23,118–37,947) compared with &U20AC;26,669 for amphotericin B (95% CI &U20AC;21,259–34,263) from the limited societal perspective. The corresponding incremental cost-effectiveness ratio was &U20AC;62 per life-week gained (i.e., &U20AC;3224 per life-year gained). Hospital costs were approximately 90% of the mean total costs. Conclusions: In the treatment of invasive aspergillosis, voriconazole is cost-effective in comparison to amphotericin B. Hospital costs are comparable for both treatments and are expected to be reimbursed based on the German diagnosis-related groups (DRG) system 2005. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10983015
- Volume :
- 9
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Value in Health
- Publication Type :
- Academic Journal
- Accession number :
- 19506960
- Full Text :
- https://doi.org/10.1111/j.1524-4733.2006.00076.x