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Loss of CD19 expression in B-cell neoplasms.
- Source :
-
Histopathology . Feb2006, Vol. 48 Issue 3, p239-246. 8p. 2 Diagrams, 1 Chart. - Publication Year :
- 2006
-
Abstract
- Aims : To investigate whether an antibody against an intracellular epitope can detect CD19 in routine biopsy specimens and thus to document in detail its expression in human lymphomas. Method and results : A polyclonal antibody to the C terminus of CD19 was used to immunostain paraffin-embedded samples of normal and neoplastic lymphoid tissues. CD19 was widely expressed in normal B cells and in extramedullary plasma cells. It was found in most B-cell neoplasms, but expression in follicular lymphoma was weak (33/69) or negative (four cases). Similarly, CD19 expression in diffuse large B-cell lymphomas was weak (28/56) or negative (eight cases). In T-cell-rich B-cell lymphomas, CD19 was also weak (4/10) or negative (three cases). CD19 was often absent in post-transplant B lymphoproliferative disease, classical Hodgkin's disease and plasma cell neoplasms. An unexpected finding was the frequent absence of CD19 in the neoplastic cells in lymphocyte predominant Hodgkin's disease. Conclusions : CD19 can now be detected in routine biopsy specimens. In contrast to the classical pan-B marker CD20, CD19 is not always strongly expressed in B-cell neoplasms. Furthermore, the lymphocytic and histiocytic (L&H) cells of lymphocyte predominant Hodgkin's disease (which express most B-cell-associated markers) commonly lack CD19. [ABSTRACT FROM AUTHOR]
- Subjects :
- *B cells
*TUMORS
*CD antigens
*EPITOPES
*LYMPHOMAS
*IMMUNOGLOBULINS
*PLASMA cells
Subjects
Details
- Language :
- English
- ISSN :
- 03090167
- Volume :
- 48
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 19448316
- Full Text :
- https://doi.org/10.1111/j.1365-2559.2005.02317.x