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Molecular and cellular mechanisms of protective immunity to coccidioidomycosis
- Source :
-
Vaccine . Jan2006, Vol. 24 Issue 4, p495-500. 6p. - Publication Year :
- 2006
-
Abstract
- Abstract: Coccidioides immitis is endemic in the soil of the desert Southwest. It causes a respiratory infection that is usually mild, but can last months and may disseminate beyond the lung. Disseminated infections can be fatal or require life-long therapy. Development of an effective vaccine may be a successful method of preventing serious disease. In this paper, we show that immunostimulatory-oligodeoxynucleotides (ISS-ODN) are an effective adjuvant for a recombinant coccidioidal protein known as antigen 2/proline rich antigen. Protective immunity induced by this ISS-ODN-based vaccine requires IL-12, interferon-γ and MHC Class II-restricted T-cells. Cytotoxic CD8 T-cells are not required. This study elucidates the mechanisms needed to elicit successful immunity against coccidioidomycosis, and holds promise for development of an effective coccidioidal vaccine against coccidioidomycosis. [Copyright &y& Elsevier]
- Subjects :
- *VACCINATION
*CYTOKINES
*IMMUNOREGULATION
*ANTIVIRAL agents
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 24
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 19339949
- Full Text :
- https://doi.org/10.1016/j.vaccine.2005.07.092