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Retroviral Restriction Factor TRIM5α Is a Trimer.
- Source :
-
Journal of Virology . Nov2005, Vol. 79 Issue 22, p14446-14450. 5p. 4 Graphs. - Publication Year :
- 2005
-
Abstract
- The retrovirus restriction factor TRIM5α targets the viral capsid soon after entry. Here we show that the TRIM5α protein oligomerizes into trimers. The TRIM5α coiled-coil and B30.2(SPRY) domains make important contributions to the formation and/or stability of the trimers. A functionally defective TRIM5α mutant with the RING and B-box 2 domains deleted can form heterotrimers with wild-type TRIM5α, accounting for the observed dominant-negative activity of the mutant protein. Trimerization potentially allows TRIM5α to interact with threefold pseudosymmetrical structures on retroviral capsids. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 79
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 19332610
- Full Text :
- https://doi.org/10.1128/JVI.79.22.14446-14450.2005