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Synthesis and biological evaluation of gem-diamine 1-N-iminosugars related to l-iduronic acid as inhibitors of heparan sulfate 2-O-sulfotransferase
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Feb2006, Vol. 16 Issue 3, p532-536. 5p. - Publication Year :
- 2006
-
Abstract
- Abstract: A variety of gem-diamine 1-N-iminosugars related to l-iduronic acid were synthesized and evaluated as inhibitors of heparan sulfate uronyl 2-O-sulfotransferase using an in vitro enzyme assay. Two iminosugars containing guanidino groups acted as potent in vitro inhibitors of the enzyme. [Copyright &y& Elsevier]
- Subjects :
- *ENZYMES
*AROMATIC amines
*ANTI-infective agents
*PHARMACEUTICAL chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 16
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 19305083
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.10.055