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DCDC2 is associated with reading disability and modulates neuronal development in the brain.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 11/22/2005, Vol. 102 Issue 47, p17053-17058. 6p. - Publication Year :
- 2005
-
Abstract
- DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large polymorphic deletion that encodes tandem repeats of putative brain-related transcription factor binding sites in intron 2 of DCDC2. Alleles of this compound repeat are in significant disequilibrium with multiple reading traits. RT-PCR data show that DCDC2 localizes to the regions of the brain where fluent reading occurs, and RNA interference studies show that down-regulation alters neuronal migration. The statistical and functional studies are complementary and are consistent with the latest clinical imaging data for RD. Thus, we propose that DCDC2 is a candidate gene for RD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Norwegian
- ISSN :
- 00278424
- Volume :
- 102
- Issue :
- 47
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 19239279
- Full Text :
- https://doi.org/10.1073/pnas.0508591102