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Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese.
- Source :
-
Alimentary Pharmacology & Therapeutics . Jan2006, Vol. 23 Issue 2, p289-294. 6p. 1 Diagram, 3 Charts. - Publication Year :
- 2006
-
Abstract
- Background Peroxisome proliferator-activated receptor γ inhibits the growth and induces apoptosis of gastric cancer cells. A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. Aim To study the association between peroxisome proliferator-activated receptor γ gene polymorphism, Helicobacter pylori infection and gastric cancer in Chinese. Methods One hundred and four consecutive patients with non-cardia gastric adenocarcinoma and 104 matched controls were examined. Peroxisome proliferator-activated receptor γ Pro12Ala polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism. Results The frequency of peroxisome proliferator-activated receptor γ G (Ala12) allele was significantly higher among cancer patients (19.2%) than in control (8.7%; OR 2.5, 95% CI 1.1–5.8). While H. pylori infection was more prevalent in gastric cancer patients (OR 3.0; 95% CI 1.6–5.7), the combination of peroxisome proliferator-activated receptor γ G allele and H. pylori infection further increased the risk of gastric cancer (OR 12.8, 95% CI 3.2–50.5). The presence of the Ala12 did not increase the risk of gastric cancer in H. pylori-negative subjects. Conclusion Our study suggests the potential association between peroxisome proliferator-activated receptor γ polymorphism and H. pylori infection in the development of non-cardia gastric cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02692813
- Volume :
- 23
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Alimentary Pharmacology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 19215603
- Full Text :
- https://doi.org/10.1111/j.1365-2036.2006.02739.x