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Pentylenetetrazole kindling induces neuronal cyclin B1 expression in rat hippocampus
- Source :
-
Neuroscience Letters . Jan2006, Vol. 392 Issue 1/2, p154-158. 5p. - Publication Year :
- 2006
-
Abstract
- Abstract: The purpose of the study was to explore the involvement of cell cycle events in the neuronal death induced by repeated seizures. Pentylenetetrazole (PTZ) kindling was used as a model of seizure-induced hippocampal neurodegeneration. Immunohistochemical approach was applied to detect cell cycle markers (cyclins and cycline-dependent kinases) in hippocampus. PTZ-kindling in rats induced moderate neuronal cell loss in hippocampal fields CA1, CA 3, CA 4, and dentate gyrus. The majority of damaged cells in hippocampi of PTZ-kindled rats were cycline B1 positive, while no expression of either other cell cycle markers or TUNEL-positive (apoptotic) nuclei could be revealed. Since cycline B1 expression has been described in hippocampal neurons of patients with temporal lobe epilepsy by [Z. Nagy, M.M. Esiri, Neuronal cyclin expression in the hippocampus in temporal lobe epilepsy, Exp. Neurol. 150 (1998) 240–247], it is suggested that PTZ-kindling may be a suitable model to study the mechanisms of seizure-induced neuronal death. [Copyright &y& Elsevier]
- Subjects :
- *BRAIN diseases
*CEREBRAL cortex
*HIPPOCAMPUS (Brain)
*GROWTH factors
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 392
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 19186061
- Full Text :
- https://doi.org/10.1016/j.neulet.2005.09.021