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Effects of olmesartan medoxomil as an angiotensin II-receptor blocker in chronic hypoxic rats
- Source :
-
European Journal of Pharmacology . Dec2005, Vol. 528 Issue 1-3, p43-51. 9p. - Publication Year :
- 2005
-
Abstract
- Abstract: We established a rat chronic alveolar hypoxia in vivo model to evaluate the efficacy against hypoxic pulmonary hypertension of a new angiotensin II-receptor I blocker, olmesartan medoxomil. Three groups of rats were established: rats exposed for 2–6 weeks to 10% oxygen atmosphere in a normobaric chamber; hypoxic rats treated with olmesartan medoxomil oral administration (5 mg/day) every day; and control rats fed in a normoxic condition. After hypoxia treatment, the presence, etiology and severity of pulmonary hypertension, was echocardiographically evaluated, and expressions of brain natriuretic peptide (BNP), transforming growth factor (TGF-β) and endothelin-1 genes measured by both immunohistochemical assay and real-time polymerase chain reaction. Olmesartan medoxomil significantly reduced the induction of hypoxic cor pulmonale not only on echocardiographical observations but also in BNP, TGF-β and endothelin gene expressions in molecular studies. However, systolic blood pressure was independent of olmesartan medoxomil. The present study clearly indicates that the angiotensin II-type I-receptor blocker olmesartan medoxomil has significant efficacy for hypoxic cor pulmonale. [Copyright &y& Elsevier]
- Subjects :
- *HEART diseases
*PULMONARY hypertension
*ETIOLOGY of diseases
*GENE expression
Subjects
Details
- Language :
- English
- ISSN :
- 00142999
- Volume :
- 528
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- European Journal of Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 19185732
- Full Text :
- https://doi.org/10.1016/j.ejphar.2005.10.063