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Transcriptional consequences of autosomal trisomy: primary gene dosage with complex downstream effects
- Source :
-
Trends in Genetics . May2005, Vol. 21 Issue 5, p249-253. 5p. - Publication Year :
- 2005
-
Abstract
- Autosomal trisomy is a common cause of human miscarriage, malformations and learning disability. Primary gene-dosage effects have been confirmed by recent transcriptome analyses. The importance (or existence) of trans-acting effects on disomic genes remains, surprisingly, controversial. In this article, I propose a model of the main genetic mechanisms that are responsible for producing the transcriptional derangement associated with trisomy. This has implications for future study design. [Copyright &y& Elsevier]
- Subjects :
- *TRISOMY
*MISCARRIAGE
*HUMAN abnormalities
*LEARNING disabilities
*GENES
Subjects
Details
- Language :
- English
- ISSN :
- 01689525
- Volume :
- 21
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Trends in Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 19175392
- Full Text :
- https://doi.org/10.1016/j.tig.2005.02.012