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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC.
- Source :
-
Nature . 6/3/1999, Vol. 399 Issue 6735, p483-487. 5p. 5 Color Photographs, 17 Black and White Photographs, 13 Graphs. - Publication Year :
- 1999
-
Abstract
- Presents research which showed that the recombinant proteins Bax and Bak accelerate the opening of the voltage-dependent anion channel (VDAC) in cells. Alteration of mitochondria in the apoptotic signal's transduction; Translocation of the protein cytochrome c in apoptosis; Role of caspases; Regulation of apoptosis by the Bcl-2 proteins; Traits of VDAC1-deficient mitochondria; Binding by Bcl-2 proteins to the VDAC.
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 399
- Issue :
- 6735
- Database :
- Academic Search Index
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 1909991
- Full Text :
- https://doi.org/10.1038/20959